HAMA Kit

Adbioink offers methacrylated hyaluronic acid. Hyaluronic acid (HA) [α-1,4-D-glucuronic acid-β-1,3-N-acetyl-D glucosamine]n, is a naturally occurring high molecular weight hydrophilic glycosaminoglycan. It is an abundant polymer in the extracellular matrix, where it provides mechanical support. Hyaluronan also provides to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions. It is a cell-friendly material and oftenly used natural polymer for cell scaffolding.

The chemical structure of HA allows (primary) hydroxyl groups to be easily replaced by esterification. Modification with methacrylate groups followed by the addition of a photoinitiator leads to polymerization upon UV exposure, resulting in network formation. Methacrylated hyaluronic acid (HaMA) is more resistant to degradation and more rigid than non-derived HA hydrogels, while retaining its biocompatibility. Methacrylation increases the final mechanical strength of HA and this results in hyaluronic acid-based hydrogels that can be 3D bioprinted. These hydrogels shows good primary cell survival and superb spontaneous osteogenic differentiation in vitro. HaMA-based hydrogels with intrinsic osteogenicity are promising scaffold materials for application in 3D printed, tissue engineered bone replacements.

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Description

HAMA Specifications;

Synonyms HAMA, HAMA Lyophilizate, Methacrylated Hyaluronic Acid, Hyaluronic Acid Methacrylate, Hyaluronic Acid Methacryloyl
Synonyms HAMA, Methacrylated Hyaluronic Acid, Hyaluronic Acid Methacrylate, Hyaluronic Acid Methacryloyl
Sterility Sterile
Degree of methacrylation 40-65%
Shelf life Minimum of 6 months from date of receipt
Shelf life after reconstitution 1 month
Storage conditions -20˚C, Light sensitive, moisture sensitive
Form Lyophilizate

 

Irgacure 2959 Specifications;

Shelf life Dry powder (non-solubilized) is stable for >1 year at 2-8°C
Storage conditions RT (room temperature)

 

LAP Specifications;

Shelf life Dry powder (non-solubilized) is stable for >1 year at 2-8°C
Storage conditions +2˚C/+8˚C

 

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